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B vitamins, including B1 (thiamine), B2 (riboflavin), and B12, also lose potency relatively quickly, especially if exposed to unfavorable storage conditions

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Addition of hydrophobic methyl group substitutions around the quinolinium scaffold (previously shown to negatively impact NNMT inhibitory activity) only slightly improved membrane permeability via passive transport as indicated by the low, but non-zero, permeability values for 1,8-diMQ and 1,2,4,8-tetraMQ (Table 4)

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