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Additionally, chronic estradiol application promotes the expression of interleukin (IL)1, IL-6, IL-12p40, and Inducible nitric oxide synthase (iNOS) in macrophages following lipopolysaccharide (LPS) stimulation, further enhancing immune responses [105]

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10.1016/S0027-5107(01)00142-7 45 KatanoK.KondoA.SafaeiR.HolzerA.SamimiG.MishimaM.et al

Safety Study-Open Label Mania Safety Data In the two long-term (six month) safety studies in pediatric patients (n= 292) between the ages of 10 and 17 years old, no clinically meaningful differences in the adverse reaction profile were observed when compared to adults