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In animal models, running increases neurogenesis in the hippocampus and angiogenesis in cortex, improving oxygen and nutrient delivery

Partecipa anche alla rimozione dei prodotti metabolici cellulari, dall'interno verso l'esterno

In fact, a study reported that L-carnitine acted to decrease ammonia levels in patients with liver cirrhosis and improved feelings of fatigue 11

Moreover, mitochondrial dysfunction and related oxidative stress can activate the innate branch of the immune system, leading to the release of pro-inflammatory cytokines influencing various depression-related pathophysiological mechanisms: monoaminergic neurotransmission disruption, tryptophan degradation toward neurotoxic catabolites, glutamate-related excitotoxicity, decreased neurotrophic factors and alterations in the hypothalamic-pituitary-adrenal axis [3, 33, 59]

589(Pt 4):963-73