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Viral infection, cholestatic dysfunction, and drug-induced liver injury (DILI) represent by far the most frequent forms of hepatic injury in secondary or acquired liver failure, which are strong predictors of an unfavorable outcome and prolonged hospitalization 13

Among them, compound 8u becomes the most effective xanthine oxidase inhibitor, with an IC50 value of 0.0288 mM, which is equivalent to febuxostat (IC50 0.0236 mM) (Zhang et al., 2019)

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