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In the DSF- and Alpelisib- PIK3 complex, residues from PIK3R1 showed larger fluctuations up to 9 , and the residues of PIK3CA involved in ligand binding (Met772, Pro778, Trp780, Ile800, Lys802, Tyr836, Glu849, Val850, Val851, Phe930, and Ile932) for both DSF and Alpelisib showed least RMSF of 1 H-bond except for PTGS2, which formed one H-bond

Cell 34 , 719726 (2015)

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Flippo KH, Trammell SA, Gillum MP, Aklan I, Perez MB, Yavuz Y, et al