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A deeper understanding on how aging, environmental stress and epigenetic regulators shape RPE lipid metabolism may ultimately reveal new therapeutic strategies that preserve PUFA homeostasis, sustain POS renewal and slow degeneration in the diseased eye

In addition, due to deterioration in mitochondrial integrity and functions, immunity decreases, and lower levels of melatonin renders older individuals to be more susceptible to impaired redox modulation and age-related diseases

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Subsequently, CCK-8 assays demonstrated that the PPARa agonist Fenofibrate enhanced cellular resistance to ferroptosis-induced death, with efficacy comparable to Fer-1, while GW6471 reduced viability (Fig