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By midlife, many adults have 40 to 50% less NAD+ than they did in their 20s

Sarcopenia and Cognitive Decline in Older Adults: Targeting the Muscle-Brain Axis

Among Ser-GSTs, only those belonging to the Phi, Tau, and Theta classes are able to catalyze such reactions, peroxisomal GSTTs being likely specialized in the reduction of fatty acid peroxides (Dixon et al., 2009)