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2021;9(11): e003254

In some experiments, mice were processed for immunocytochemistry (see below) two hours after ip IGF-I injection to allow expression of c-fos, whereas in other experiments PeF recordings were carried out immediately after ip injection

Their mode of action can be paracrine (acting on neighboring cells), autocrine (activating receptors on the cells that synthesized them), or endocrine (acting at a distance, via the circulation) 25 (Fig

168 Based on the findings above, maintaining the normal activity of p53 via proper regulation is suggested to be essential for avoiding aging phenotype formation and can also protect the organism from immunosenescence