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Results: The results of the present study revealed a significant increase in TSH hormone (2.23 0.44) and epinephrine hormone (371.74 24.29) in the hypothyroid group compared with the control group, while there is a significant decrease in cortisol hormone (88 17.97) and vitamin B12 (297.52 12.51) in the hypothyroid group compared with the control group, where the level of hormones in the (hypothyroid rats +B12) group became close to the level of hormones in the control group as well as significantly decreased TSH and epinephrine levels and increased cortisol and vitamin B12 serum levels

Vitamin B12 Deficiencies Vitamin B12 is necessary for patients with a low serum level of vitamin B12 because they take particular medications or because they suffer from: Pernicious anemia Gastrointestinal or autoimmune disorders Alcoholism Patients may also have low levels of vitamin B12 if they have had bariatric surgery, are strict vegetarians, or have used antacids or proton pump inhibitors for a prolonged period