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Across diverse cell sources (dental pulp, mesenchyme, olfactory mucosa, induced pluripotent cells, Tregs and even homeostatic M2 microglia) the common therapeutic denominator is delivery of RNA cargo that throttles one of three pressure points in the pyroptotic cascade: (i) inflammasome activation (NLRP3 or AIM2), (ii) execution (GSDMD) or (iii) transcriptional priming (NF-B/NKAP)

Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-

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doi: 10.1016/j.ecoenv.2020.111682 29

The specific training protocol (volume, intensity, frequency) influences how quickly adaptations occur