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Each has a known fix

doi: 10.1089/ast.2006.6.463, 42 HanR.ZhangX.LiuJ.LongQ.ChenL.LiuD.et al

Tirzepatide binds to both GIP and GLP-1 receptors, with the GIP component potentially offering additional benefits for weight reduction and metabolic parameters beyond GLP-1 agonism alone