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4.5 Pazopanib Pazopanib is an orally available and selective tyrosine kinase inhibitor against targets such as VEGFR-1/-2/-3 and PDGFR to inhibit angiogenesis, which has been approved for advanced kidney cancer and soft tissue sarcoma treatment (145, 146)

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Other studies have demonstrated elevated activities of SOD1 and SOD2 within active demyelinating lesions (Kemp et al., 2016) and in the cerebellar gray matter of MS patients (van Horssen et al., 2008), as well as increased CAT activity in active lesions (van Horssen et al., 2008)