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2013;304:C137146

Kynurenic acid is thought to have protective effects on mitochondrial respiration, whereas accumulation of quinolinic acid is associated with mitochondrial dysfunction (71)

It was developed at the University of Arizona by Hruby and Hadley and contains two key modifications from native -MSH: a norleucine substitution at position 4 (replacing methionine) and a D-phenylalanine substitution at position 7 (replacing L-phenylalanine)