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Retinal neovascularization occurs in 36% of eyes with an area of non-perfusion greater than 5 disc diameter.54 RVO is associated with an increase in vascular causes of death (both cerebral and cardiac) in large prospective follow-up studies.55 In all patients with RVO, the systemic risk factors (hypertension, diabetes mellitus, blood lipid disorders) should be investigated and managed by appropriate specialists

2018 Jan 31;7(1):e2

Deficiencies in B12 can directly lead to nerve damage and worsen symptoms of diabetic neuropathy.65 While most people can get adequate B12 through diet (meat, fish, dairy, fortified cereals), certain medications including metformin and proton pump inhibitors can impair absorption and raise the risk of deficiency