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Blockade of tumor cell transforming growth factor-s enhances cell cycle progression and sensitizes human breast carcinoma cells to cytotoxic chemotherapy

The rs1001179 variant (also known as C-262T) resides in the promoter region of the CAT gene (262 from the transcription start site in the 5-UTR), where it affects transcription factor binding and subsequently alters CAT expression levels (Liu et al., 2016)

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To create molecularly focused therapies that can change the course of the illness rather than merely manage its symptoms, it is necessary to map the sequential path from airway to damage to systemic and neurological harm [107, 108]