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A case-control study (50 domestic shorthair cats with a confirmed diagnosis of FISS and 100 disease-free matched controls) investigating a possible association between polymorphisms in the genomic sequence of the feline p53 gene and a predisposition to FISS, found a strong association between FISS and the presence of specific nucleotides at two of the polymorphic sites (Banerji et al., 2007)

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Common negative reports include increased injection site discomfort, slightly more GI upset (particularly during the first few weeks), and disappointment when the dramatic results promised by marketing materials do not materialize

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