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19 Most Addictive Substances and Their Risks Avenues Recovery On Science: Can you smoke cigarettes without becoming addicted? STLPR A Molecular Basis for Nicotine as a Gateway Drug New England Journal of Medicine Most tobacco products, including e cigarettes, contain nicotine, a chemical that can harm the heart, brain and whole body. As with other addictive products, using a nicotine product builds tolerance, leading to more Tobacco Addiction Guide: Symptoms, Risks & Recovery
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