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Tsimberidou AM, Tirado-Gomez M, Andreeff M , O'Brien S, Kantarjian H, Keating M, Lopez-Berestein G, Estey E

10.1073/pnas.0813132106 [DOI] [PMC free article] [PubMed] [Google Scholar] 33.Thomas DT et al

This reduces tissue damage and inflammatory signalling by inhibiting the maturation of IL-1 and IL-18 mediated by caspase-1 ( FIGURE 4 3.3 Organ-specific protective activities To gain a deeper understanding of the pharmacological actions of silymarin, it is essential to examine the organ-specific mechanisms through which silymarin exerts its effects (Table 2)

Further research is essential to discover new strains, optimize dosing regimens, confirm safety, and validate health claims through robust clinical trials