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HPLC consumables and solvents were from Agilent Technologies (Mississauga, ON, Canada), and Fisher Scientific (Mississauga, ON, Canada), respectively

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In the senescent state, FOXO4 accumulates in PML (promyelocytic leukemia) nuclear bodies where it binds and sequesters p53, preventing p53 from activating the mitochondrial apoptotic pathway

After 12 weeks, the HCP group showed significant improvement in skin elasticity, hydration, and roughness compared with baseline and placebo-control values

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