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2013 Nov;61: 203-8

J Vet Intern Med (2022) 36:17529

However, there are no hepatitis B vaccines used for therapeutic purposes in clinical practice mainly because most of the recombinant protein vaccines currently under development target HBsAg as a single antigen, which cannot induce a multi-antigen-specific immune response, thus failing to activate low-reactive specific T cells that persist in the subjects bodies