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EETs, metabolites of the CYP450 pathway, have been shown to reduce liver lipid peroxidation and inflammation in NASH mice through PPAR and NF-B signaling pathways (14, 15, 27, 39), highlighting their anti-inflammatory potential in various diseases (1719)

Cellular senescence is immunogenic and promotes antitumor immunity

NAC may benefit protamination by feeding the one-carbon metabolism, which, besides increasing GSH and antioxidant capacity of sperm, provides activated methyl groups for epigenetic DNA reprogramming [35]

Starting at a lower dose and gradually increasing under medical supervision is advised

a sample from a healthy subject not suffering from the biomarker-related disease) and preferably the average biomarker expression level in several control samples is at least 10% and more preferably 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20-fold or more