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Description

Accumulation of free radicals coupled with an increase in oxidative stress has been implicated in the pathogenesis of several disease states

Oncogenesis (2016) 5:e189

This has driven the need for new therapeutic approaches

This reaction is catalyzed by 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2)

The effect in these early weeks is often described as a noticeable reduction in the intensity of hunger signals rather than complete appetite suppression