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Furthermore, multilayer PLLA nanosheets were developed to deliver FGF-2 for the repair of femoral defects, and the findings indicated that these scaffolds gradually released FGF-2 over 2 weeks when implanted subcutaneously in vivo [315]

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Recent advances in targeted strategies for triple-negative breast cancer

We therefore functionalized CCW16 as a POI recruitment ligand and designed a series of PROTACs, where CCW16 was linked to VHL032- and 4-hydroxy thalidomide-derived-E3 ligands, recruiting the E3 ligases VHL and CRBN, respectively