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Here, we employed AlphaFold2, molecular dynamics (MD) simulations, ZDOCK and Rosetta to accurately estimate nanobody stability and affinity change upon ncAA mutation (Fig

Faber, J

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The primary outcome measure was safety, and key secondary outcomes were mean change from baseline best- corrected visual acuity (BCVA), mean change from baseline macular sensitivity measured by microperimetry, change from baseline in ellipsoid zone width at weeks 12 and 24, and NAC levels in the aqueous humor and in plasma