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Drug Metab Dispos 46(10):1403

Wnt/-catenin signalling pathway has shown strong immunosuppressive function in a variety of tumours, and potentially become a novel target of tumour treatment

Cdkn2 -/- ) cell lines were obtained from and authenticated by ATCC

Selective Bcl-xL inhibitors include a vaccine for prostate cancer and ABBV-155, an antibody-drug conjugate being studied as monotherapy or for use in combination with taxanes for solid tumors (Walensky et al., 2004)