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Good nutrition may reduce the incidence of prostate cancer and help reduce the risk of prostate cancer progression (Miller et al 2012)

Vit.E is a potent lipid-soluble antioxidant naturally occurring within cells, tends to accumulate in the membranes of mitochondria and endoplasmic reticulum

Further, we compared the extracted mutational signatures with known SBS signatures in the COSMIC database, ultimately identifying SBS4 (smoking related), SBS5 (unknown etiology), SBS13 (APOBEC cytidine deaminase related), SBS40 (unknown etiology), and SBS60 (sequencing artefact) signatures (Fig