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Although the pentose phosphate pathway and glycolysis are well recognized as the primary sources of NADPH that contribute to redox balance, the folate cycle ( Figure 3 )which is mostly sustained by serine-derived one-carbon unitsalso generates a significant amount of NADPH (238)

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The effect is relatively rapid because NAD+ replenishment works at the cellular level without requiring the body to upregulate a downstream hormonal cascade