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Interaction between the IVR domain of Keap1 and the NH2-terminal region of CUL3 forms the Keap1-CUL3 complex ( FIGURE 2 Nrf2: The Central node of Keap1-Nrf2 Pathway Nrf2 regulates the induction of the genes related to the generation of NADPH, which is further used by many redox reactions, including malic enzyme 1, 6-phosphogluconate dehydrogenase, isocitrate dehydrogenase 1 and glucose 6-phosphate dehydrogenase ( Nrf2 contains six highly conserved homology domains which are termed Neh1 (Nrf2-ECH homology domain-1) Neh6 (Figure 2)

It may be particularly beneficial for individuals living in food-insecure regions, especially those with low calcium and potassium diets (Badejo et al., 2020)

Whether this mechanism is commonly employed for a variety of substrates and whether monothiol mechanisms (i) and (ii) are really relevant for the reduction of other non-glutathione disulfide substrates remains to be analyzed

The Oncologist , 22 (3), 243e223

reduction of the inflammatory response upon infection