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10.1016/j.chroma.2004.08.152 499

While mechanisms underlying this systemic autoimmune response remain largely unknown, several vital studies show that uncontrolled reactive oxygen generation and defect in regulation of antioxidant system are, in part, crucial factors for the pathogenesis of SLE [85]

While the xIBB stabilizes the most extended conformation (around 110 ), Ran-GTP instead strains the importin solenoid, resulting in a globular assembly of roughly 85 (Fig