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At day 21, four rabbits in the TCC group and three in the zinc oxide group achieved complete coverage with granulation tissue and epithelialization, with mean healing times of 18.4 and 21.5 days, respectively

Furthermore, given that we have demonstrated that this mitochondrial adaptation is to promote rebalancing of pyrimidine levels, mitochondrial biogenesis could also be used to identify patient cohorts likely to benefit from UCK2 inhibitor combinations

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A platinum fluoropyrimidine doublet has been the first-line therapy due to lower toxicity (3)

Orphanet J Rare Dis 16:177