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Comorbid patients have significantly elevated plasma kynurenine/tryptophan ratios, positively correlated with both constipation severity and depression scores (Myint and Kim, 2014)

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Moreover, as effective antioxidants, both acids can break glycation-oxidation vicious cycle that leads to AGE formation

doi: 10.1016/S0264-410X(00)00257-7 242 MurphyJR