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Newer data reveal the role of the autocrine-paracrine micro-regulation of ACTH-mediated cortisol synthesis by a large number of intra-adrenally produced factors deriving from chromaffin cells, resident immune cells, intra- and peri-adrenal adipocytes, and adrenal innervation

What does this mean for healthy aging

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Now, there's a law of diminishing returns, like a lot of people who eat a very acidic diet, way too many inflammatory foods, etc., or even just exercise have produced too much lactic acid from excessive hard exercise

doi: 10.1038/nrmicro.2016.17 228 StepankovaR.TonarZ.BartovaJ.NedorostL.RossmanP.PoledneR.et al (2010)