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17 Of particular interest, PPA is a known inhibitor of mitochondrial function, through sequestration of carnitine and the production of propionyl-CoA, a potential cytotoxin

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In many countries, serum TSH concentration is used in the screening for congenital hypothyroidism in newborns

In addition to electronic database searches, manual searches were performed using Google Scholar, and the reference lists of all relevant primary and secondary sources were screened to identify additional eligible studies and gray literature