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XiaoMZhuTZhangWWangTShenYCWanQFet al

Dosage modifications or discontinuation may be necessary if abnormalities in laboratory parameters are observed

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10.1016/S1470-2045(13)70240-7 331 SariA

Dysregulation of the tyrosinase enzyme is the main cause of melanogenesis inhibition Hyperpigmentation is the darkening or increase in the natural color of the skin usually due to an increased deposition of melanin (hypermelanosis) Less frequently, it may be caused by the deposition in the dermis of endogenous or exogenous pigments, such as hemosiderin, iron, or heavy metals The excess of melanin in the basal and suprabasal layers of the skin is due to either an abnormally high number of melanocytes or a normal melanocyte population