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Therefore, comprehensive mechanistic studies are necessary to elucidate vitamin metabolism and its spatiotemporal modulation across various malignancies, thereby facilitating the translation of this knowledge into clinical therapies

James SH, Kimberlin DW, Whitley RJ

Inflammatory macrophages are the major contributor to necrotic core formation, yet TREM2+ macrophages have recently been shown to have low expression of inflammatory genes and a beneficial role in atherosclerosis 97,98,99,100,101,102