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Abbreviations IRI: Ischemia-reperfusion injury ROS: Reactive Oxygen Species RNS: Reactive Nitrogen Species BBB: Blood-Brain Barrier HIFs: Hypoxia-Inducible Factors PHD: Prolyl Hydroxylase NRF2: Nuclear Factor Erythroid 2Related Factor 2 NF-kB: Nuclear Factor kappa-light-chain-enhancer of activated B cells MAPK: Mitogen-Activated Protein Kinase VEGF: Vascular Endothelial Growth Factor VEGF-R1: Vascular Endothelial Growth Factor Receptor 1 VEGF-R2: Vascular Endothelial Growth Factor Receptor 2 MMPs: Matrix Metalloproteinases SOD: Superoxide Dismutase CAT: Catalase GPX: Glutathione Peroxidase DNA: Deoxyribonucleic Acid NO: Nitric Oxide ATP: Adenosine Triphosphate ETC: Electron Transport Chain mPTP: Mitochondrial Permeability Transition Pore GPX4: Glutathione Peroxidase 4 NOS: Nitric Oxide Synthase ASU: Avocado Soybean Unsaponifiable MUFAs: Monounsaturated Fatty Acids PUFAs: Polyunsaturated Fatty Acids MF: Monounsaturated Fatty acid References Soares ROS, Losada DM, Jordani MC et al (2019) Ischemia/reperfusion injury revisited: an overview of the latest pharmacological strategies

Methylation by Set7/9 negatively regulates Sirt1 deacetylation activity

HGH has several known metabolic functions, including induction of insulin-like growth factor-1 (IGF-1) and lipid and carbohydrate metabolism