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Its ability to activate sirtuins, enhance DNA repair, regulate metabolism, influence fat cell metabolism in preclinical models and support mitochondrial health positions it as a compelling candidate for further investigation

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The amino acid sequence of rat liver G6PD shows 94% homology to the human sequence and provides evidence that the N-terminal amino acid is N -acetylalanine, which must result from posttranslational cleavage of the N-terminal methionine

In particular, DBG + US treatment possessed a better inhibitory effect on distal tumor growth than the BG + US treatment, which is attributed to the amplification of anticancer immunity by 2-DG-mediated N-glycosylation inhibition

Therefore, exploring the role of ferroptosis in the occurrence and development of PCOS can provide more ideas for mechanistic research on PCOS and more potential targets for PCOS treatment