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Circulation 139 (9), 12371239 (2019)

Nature 472 , 486490 (2011)

Glutathione deficiency can lead to various health issues

BCA also exerts a neuroprotective effect against L-glutamate-induced cytotoxicity, which plays a crucial role in neuronal cell death in various neurodegenerative diseases 44,45 while PHL, a -dicarbonyl enols scavenges electrophile metal ions & unsaturated aldehyde through their nucleophile enolate form and becomes a rational candidate for treatment of oxidative stress linked disorders 45,46

Most MS patients, over time and aging, switch to a progressive phase characterized by a gradual clinical decline with progressive deterioration of neurological functions, due to continuous axonal degeneration ( The mechanism of MS pathology involves complex interactions between systems and cell types, such as neurons, glia, and immune cells, which lead to focal lesions of inflammatory demyelination and widespread neurodegeneration in the brain and spinal cord