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In terms of reproductive endocrinology, LBP has been shown to upregulate hormones associated with the HPG axis, such as GnRH, FSH, and LH, thereby promoting the synthesis and secretion of T, which is essential for spermatogenesis ( These studies consistently demonstrate that Lycii Fructus promotes spermatogenesis and sperm maturation, increases intratesticular T, enhances sperm quality, and reduces oxidative damage and apoptosis in testicular tissues

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Funding This work was supported by the Deutsche Forschungsgemeinschaft (DFG) SFB-TR 338 (LETSimmun)project number: 452881907, SFB 1526 (PANTAU), project number: 454193335

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This result is consistent with the higher average concentration of RBD in the 500LBR2 (ss2) process (85 mg/L) compared to the 500LBR1 process (60 mg/L)