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Direct or indirect indices of progesterone production: Urinary or serum luteinizing hormone (LH) rise A rise in basal body temperature Increase in serum progesterone Menstruation following a shift in basal body temperature Sonographic evidence of ovulation: Collapsed follicle Fluid in the cul-de-sac Features consistent with corpus luteum formation Secretory endometrium 6 ADVERSE REACTIONS The following serious adverse reactions are discussed elsewhere in the labeling: Hypersensitivity Reactions and Anaphylaxis [see Warnings and Precautions (5.1)] Ovarian Hyperstimulation Syndrome [see Warnings and Precautions (5.2)] Pulmonary and Vascular Complication [see Warnings and Precautions (5.3)] Ovarian Torsion [see Warnings and Precautions (5.4)] Abnormal Ovarian Enlargement [see Warnings and Precautions (5.5)] Multi-fetal Gestation and Birth [see Warnings and Precautions (5.6)] Embryofetal Toxicity [see Warnings and Precautions (5.7)] Ectopic Pregnancy [see Warnings and Precautions (5.8)] Spontaneous Abortion [see Warnings and Precautions (5.9)] Ovarian Neoplasms [see Warnings and Precautions (5.10)] 6.1 Clinical Study Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trial of another drug and may not reflect the rates observed in practice

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In vitro human systems, organ-on-chip, in silico and PBPK models, omics-based assays

They may be worth considering if: Your dog is dealing with chronic inflammation or joint problems You're looking for a recovery aid after surgery or injury You want a natural option to complement other treatments Your pet has plateaued with standard care However, they shouldnt replace foundational health strategies like proper nutrition, exercise, and routine veterinary checkups

This is especially true if you are recovering from surgery