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The Data of the phase 1 single ascending dose trial suggest that the dose was well tolerated and showed potential to reduce body weight [25]

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3.2 GDC decreases TEER with subsequent recovery To assess the effect of non-cytotoxic GDC on the intestinal barrier integrity, 25-day old differentiated Caco-2/HT29-MTX 90:10 monolayers were exposed for 2 h to 0.5, 0.8 and 1 mM GDC