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At later time points, negative regulators of the PI3K/AKT/mTOR pathway are induced, inhibiting mTORC1 activity and inducing autophagy (107)

However, cuproptosis may not take place in the endothelial cells because they cells are Cu deficient under the condition of atherosclerosis [138, 139]

The underlying mechanism involves the Wnt/beta-catenin signaling pathway, which plays a key role in the regulation of the hair cycle