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Its analgesic and antipyretic properties stem from two key mechanisms: selectively inhibiting COX (Cyclooxygenase) enzymes in the brain to block PGE2 prostaglandins (the fever and pain-signaling chemicals), and newer theories suggest a contribution from an active metabolite called AM404

Despite what supplement makers have led you to believe, there is no scientific evidence that vitamin C directly prevents colds and flu viruses

Elimination: Renal clearance may account for about 30% of the total body clearance

10.1016/j.febslet.2009.11.037 [DOI] [PubMed] [Google Scholar] Frechin M, Enkler L, Tetaud E, Laporte D, Senger B, Blancard C, Hammann P, Bader G, Clauder-Mnster S, Steinmetz LM, et al

Suppression of murine thyroiditis via blockade of the CD40-CD40L interaction