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These factors include habitat degradation and shrinkage, crop monoculture, excessive pesticide use, the presence of pathogens and parasites, inadequate forage nutrient content, and the detrimental impacts of climate change 3

doi: 10.1155/2014/360438 10 AyerA.ZarjouA.AgarwalA.StockerR

In contrast, DHODH is anchored within the inner mitochondrial membrane and couples the oxidation of dihydroorotate to orotate with CoQ reduction, producing a localized reservoir of CoQH that specifically protects mitochondrial membranes from ferroptotic damage