glutathione imbalance between antioxidant defenses and reactive oxygen species Intracellular and extracellular glutathione redox

In Polycystic Ovary Syndrome (PCOS) oxidative stress (inflammation) has been shown to be involved in mediating insulin resistance and androgen hormone increases

Present in nearly every cell, it plays a pivotal role in preserving cellular integrity, neutralizing harmful oxidants, and sustaining metabolic equilibrium

10.1186/s13059-015-0692-3 129 KlepeisJ

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

This novel feature of TNBS to wear off GSH, coupled with its potential for ROS generation, demonstrates that TNBS promotes two independent mechanisms of injury, namely, GSH limitation and ROS accumulation, which in cooperation trigger a chain of processes that lead to cell damage