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We obtained a mutant strain containing the ifd-1(ok2404) deletion (1863 base pairs deleted) and used CRISPR/Cas9 technology to generate deletion allele ifd-2 ( bz187) , which is missing the ifd-2 start codon and the first three ifd-2 exons are affected

This high-dose CKRT resulted in clearance rates (that is, total replacement and/or Qd) of up to 8,000 ml/1.73 m 2 /h or more and was safe for the patients 34