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An increase in BUN within the first 24 h is now recognized as a significant risk factor for mortality and is closely associated with multiple organ failure and severe disease progression

It is suggested that the methionine residue at position 358 in hAAT is sterically exposed and readily oxidized 54

Langan et al, 2020

Other causes Other causes of acute liver failure include ischemic hepatitis, autoimmune hepatitis, Wilson disease, Budd-Chiari syndrome, and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome

This is why experts often recommend monitored use rather than continuous, self-prescribed intake