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ABHD5 stimulates PNPLA1-mediated O -acylceramide biosynthesis essential for a functional skin permeability barrier

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Abbreviations AchE: Acetylcholinesterase AdoMet: S-adenosylmethionine AD: Alzheimers disease AFM: Atomic force microscopy A: Amyloid-beta BchE: Butyrylcholinesterase Bcl-2: B-cell lymphoma BHK: Baby hamster kidney BSA: Bovine serum albumin CAM: Chicken chorioallantoic membrane DCFH-DA: 2,7-Dichlorodihydrofluorescein diacetate DTPA: Diethylenetriaminepentaacetate CD: Circular dichroism CHIKV: Chikungunya virus ChEIs: Cholinesterase inhibitors CSF: Cerebrospinal fluid dsRNA: Double-stranded RNA EB: Ethidium bromide ECM: Extracellular matrix FAAS: Flame atomic absorption spectroscopy -Gly: -Glycosidase H 2 O 2 : Hydrogen peroxide HO : Hydroxyl HIF-: Hypoxia-inducible factor IZD: Inhibition zone diameter MBC: Minimum bactericidal concentration MIC: Minimum inhibitory concentration MMP: Mitochondrial membrane potential MFC: Minimum fungicidal concentration MSR: Methionine synthase reductase MoM: Metal-on-metal nsP4: Non-structural protein 4 O 2 : Superoxide RBD: Receptor binding domain SEM: Scanning electron microscopy SI: Selectivity index ROS: Reactive oxygen species TEM: Transmission electron microscopy UTP: Uridine 5-triphosphate VSV: Vesicular stomatitis virus VZV: Varicella-zoster virus References Chang EL, Simmers C, Knight DA (2010) Cobalt complexes as antiviral and antibacterial agents

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