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This includes adaptive trial designs in which treatment can be modified in response to on-therapy biomarker trajectories, longitudinal monitoring enabled by liquid biopsy to noninvasively track the evolution of epigenetic networks [387], and the integration of multi-omics time-series data using artificial intelligence to build predictive models that guide individualized interventions

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In one such effort, manganese-containing biscyclohexylpyridine complex (M40403), was synthesized, which exhibited SOD enzyme-like activities but only to a certain extent (Muscoli et al., 9 M 1 s 1 and 1.1 10 5 M 1 s 1 , respectively) (Korsvik et al., 9 M 1 s 1 ) for their SOD activity, the former showed better scavenging of superoxide radicals than the authentic enzyme itself

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PBMC TL assays were performed using a qPCR method with an oligonucleotide quantitation standard