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Notably, the EBOV polymerase structure we present here exhibits a contracted conformation that has not been described before, characterized by a shrunken central cavity and a narrowed template entry channel, suggesting a distinct state in the RNA synthesis process

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doi:10.1097/ogx.0000000000000732 Lee CC, Su YC, Chien SH, et al

Adjust the dose based on the patients INR and the condition being treated